• Producer : John Davis , John Fox , Beau Flynn
• Director : Jaume Collet-Serra
• Art. Director : Jaume Collet-Serra
• Editor : Jaume Collet-Serra
• Screenwriter- screenplay : Michael Green , Glenn Ficarra , John Requa
• Story : John Norville as (- Based onWalt Disney's Jungle Cruise ), Josh Goldstein , Glenn Ficarra , John Requa
• Composer : James Newton Howard
• Actress : EMILY BLUNT , Édgar Ramírez
• Actor : Jack Whitehall

In 1556, Don Aguirre leads Spanish conquistadors to South America to search for the Lágrimas de Cristal[b] Tree, whose flowers cure illness, heal injuries, and lift curses. After many conquistadors die, the Puka Michuna tribe heals the sickened survivors with the Tree's flowers. When the tribal chief refuses to reveal the Tree's location, Aguirre stabs him and burns the village. The dying chief curses the conquistadors, making them immortal and unable to leave sight of the Amazon River without being dragged back by the jungle itself. In 1916 London, Dr. Lily Houghton's Tears of the Moon research is presented by her brother MacGregor to the Royal Society. The Houghtons, hoping to revolutionize both medicine and the British War Effort, request access to a recently acquired arrowhead artifact, but the request is denied as the Tree is considered myth and female scientists are disfavored. However, believing the arrowhead and her old Amazon map are the key to finding the Tree, Lily steals it, narrowly evading Prince Joachim, who is equally intent on finding the Tree for Germany. Arriving in the First Brazilian Republic, Lily and MacGregor search for a guide to navigate the Amazon River. They hire skipper Frank Wolff who offers jungle cruises embellished with faked theatrical dangers and corny puns. He initially declines, citing the dangers of the river and jungle. Frank reconsiders upon seeing the arrowhead. Frank steals back his repossessed boat engine from the harbormaster Nilo and the trio departs after escaping from Joachim's U-boat. In Frank's cabin, Lily finds photos and sketches of modern inventions as well as research on the Tears of the Moon. She accuses him of seeking the Tree, but he insists he gave up long ago. They are captured by the Puka Michuna tribe, disguised as cannibals, but quickly release them as they were hired by Frank. Angered, Lily begins to doubt Frank. The tribal chief Trader Sam translates the symbols on the arrowhead, revealing the Tree's location and that it only blooms under a blood moon. Meanwhile, Joachim has located the conquistadors petrified inside a cave. He makes them agree to find the arrowhead for him in exchange for flowers. He diverts the river to free them and they are reanimated while fused with rainforest elements. The conquistadors track down and attack the tribe where Frank is stabbed through the heart. Lily flees with the artifact, but vines pull the Spaniards away when they unknowingly lose sight of the river while pursuing her. To the Houghtons' amazement, Frank reappears alive. He reveals he is one of the cursed conquistadors, who once wanted to help find the Tears to save Aguirre's paralyzed daughter. However, he sided with the tribe against Aguirre's rampage. After years of fighting, he trapped his vengeful comrades away from the river's view, petrifying them. Failing to find the Tree, Frank became a tour guide and built a village. Lily and Frank continue to La Luna Rota[c] Waterfall and uncover a submerged temple. Meanwhile, Joachim has captured MacGregor and forces him to reveal Lily's location. Frank, the Houghtons, the Germans, and the conquistadors all converge at the Tree when La Luna Rota's water is partially drained. Discovering the arrowhead is a locket with a red gem inside, Lily places the two pieces into carvings in the bark and the Tree briefly blooms under the blood moon. As a fight ensues, Lily recovers one flower. The German soldiers drown, Joachim is crushed by falling rock, and Frank crashes his boat to block the river, petrifying himself and the rest of the conquistadors to save Lily. Realizing her true feelings for Frank, Lily sacrifices the flower to lift Frank's curse and restore his mortality, and he decides to leave the Amazon to be with her. The moon's last beam blooms a single flower, which Lily takes for research. Returning to port, Frank sells his business to Nilo. Upon their successful return to Britain, Lily becomes a full professor at the University of Cambridge. MacGregor rejects an invitation of membership from the Royal Society. Lily and Frank then explore London together.